High-throughput cytochrome P450 (CYP) inhibition screening via cassette probe-dosing strategy

Cytochrome P450 isoform inhibitors as a tool for the investigation of metabolic reactions catalyzed by human liver microsomes.

Martine Bourrié, Viviane Meunier, Yves Berger et al. · Journal of Pharmacology and Experimental Therapeutics · 1996 · 362 citations

Medicine, Biochemistry, Pharmacology +15

Validation of the five-drug “Pittsburgh cocktail” approach for assessment of selective regulation of drug-metabolizing enzymes*

Reginald F. Frye, Gary R. Matzke, Adedayo Adedoyin et al. · Clinical Pharmacology & Therapeutics · 1997 · 241 citations

Medicine, Pharmacokinetics, Pharmacology +14

CYP2D6- and CYP3A-dependent metabolism of dextromethorphan in humans

Évelyne Jacqz-Aigrain, Christian Funck‐Brentano, Thierry Cresteil · Pharmacogenetics · 1993 · 144 citations

Medicine, Biochemistry, Pharmacology +14

Fully automated analysis of activities catalysed by the major human liver cytochrome P450 (CYP) enzymes: assessment of human CYP inhibition potential

Graeme C. Moody · Xenobiotica · 1999 · 143 citations

Medicine, Pharmacokinetics, Pharmacology +17

Determination of a ‘GW cocktail’ of cytochrome P450 probe substrates and their metabolites in plasma and urine using automated solid phase extraction and fast gradient liquid chromatography tandem mass spectrometry

Rebecca J. Scott, Jonathan Palmer, Ivor A. S. Lewis et al. · Rapid Communications in Mass Spectrometry · 1999 · 119 citations

Medicine, Biochemistry, Pharmacology +17