Concepedia

P-glycoprotein and breast cancer resistance protein restrict the brain penetration of the CDK4/6 inhibitor palbociclib

Mark C. de Gooijer, Ping Zhang, Nishita Thota, Isabel Mayayo‐Peralta, Levi C.M. Buil, Jos H. Beijnen, Olaf van Tellingen

Investigational New Drugs · 2015 · 85 citations · 19 references

Concepts

MedicineOncologyPharmacologyCancer PharmacologyChemotherapyMolecular OncologyBlood-brain Barrier PenetrationBrain TumorsBreast Cancer PharmacotherapyPharmacodynamics Of Anticancer AgentsTherapeutic ResistanceTyrosine Kinase InhibitorsAnticancer Drug ResistanceCdk InhibitorsCyclin-dependent Kinase 4 InhibitorsCyclin-dependent Kinase 4/6 InhibitorsCyclin-dependent Kinase 6 InhibitorsKinase InhibitorsProtein Kinase Inhibitors

References

19

Radiotherapy plus Concomitant and Adjuvant Temozolomide for Glioblastoma

Roger Stupp, Warren Mason, Martin J. van den Bent et al. · New England Journal of Medicine · 2005 · 21.6K citations · Full text

Medicine, Oncology, Radiation Oncology +12

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

Nature · 2008 · 7.8K citations · Full text

Medicine, Molecular Genetics, Oncology +12

The Somatic Genomic Landscape of Glioblastoma

Cameron Brennan, Roel G.W. Verhaak, Aaron McKenna et al. · Cell · 2013 · 5.2K citations · Full text

Medicine, Genetics, Molecular Genetics +12

PKSolver: An add-in program for pharmacokinetic and pharmacodynamic data analysis in Microsoft Excel

Yong Zhang, Meirong Huo, Jianping Zhou et al. · Computer Methods and Programs in Biomedicine · 2010 · 2.1K citations

Pharmacy, Pharmacokinetics, Pharmacology +7

PD 0332991, a selective cyclin D kinase 4/6 inhibitor, preferentially inhibits proliferation of luminal estrogen receptor-positive human breast cancer cell lines in vitro

Richard S. Finn, Judy Dering, Dylan Conklin et al. · Breast Cancer Research · 2009 · 1.4K citations · Full text

Medicine, Oncology, Pharmacology +17