PIKE

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

Anne J. Ridley, Hugh F. Paterson, Caroline L. Johnston et al. · Cell · 1992 · 3.6K citations

Signal Transduction, Developmental Biology, G Protein-coupled Receptor +8

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα

Dario R. Alessi, Stephen R. James, C. Peter Downes et al. · Current Biology · 1997 · 2.8K citations · Full text

Signal Transduction, Molecular Physiology, Signaling Pathway +11

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

Thomas Franke, Sung‐Il Yang, Tung O. Chan et al. · Cell · 1995 · 2K citations · Full text

Akt Proto-oncogene, Signal Transduction, Signaling Pathway +11

Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP

Johan de Rooij, Fried Zwartkruis, Mark H. G. Verheijen et al. · Nature · 1998 · 2K citations

Signal Transduction, Molecular Physiology, Biochemistry +7

Mammalian Ras interacts directly with the serine/threonine kinase raf

Anne B. Vojtek, Stanley M. Hollenberg, Jonathan A. Cooper · Cell · 1993 · 2K citations

Signal Transduction, Molecular Physiology, Serine/threonine Kinase Raf +6