Effects on differentiation by the promyelocytic leukemia PML/RARalpha protein depend on the fusion of the PML protein dimerization and RARalpha DNA binding domains.

Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D3 signalling

Steven A. Kliewer, Kazuhiko Umesono, David J. Mangelsdorf et al. · Nature · 1992 · 1.5K citations · Full text

Developmental Biology, Signal Transduction, Retinoic Acid +7

Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RARα with a novel putative transcription factor, PML

Akira Kakizuka, Wilson H. Miller, Kazuhiko Umesono et al. · Cell · 1991 · 1.4K citations · Full text

Hematological Malignancy, Chromatin, Transcriptional Regulation +9

The PML-RARα fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR

Hugues de Thé, Catherine Lavau, Agnès Marchio et al. · Cell · 1991 · 1.4K citations

Hematological Malignancy, Transcriptional Regulation, Pml-rarα Fusion Mrna +8

A segment of the 5' nontranslated region of encephalomyocarditis virus RNA directs internal entry of ribosomes during in vitro translation

Sung Key Jang, Hans‐Georg Kräusslich, Martin J.H. Nicklin et al. · Journal of Virology · 1988 · 1.3K citations · Full text

Viral Replication, Immunology, Molecular Biology +16

RXRβ: A coregulator that enhances binding of retinoic acid, thyroid hormone, and vitamin D receptors to their cognate response elements

Victor C. Yu, Claude Delsert, Bogi Andersen et al. · Cell · 1991 · 1.2K citations

Signal Transduction, Medicine, Vitamin D Receptors +9