Cytoplasmic Nucleophosmin in Acute Myelogenous Leukemia with a Normal Karyotype

Brunangelo Falini, Cristina Mecucci, Enrico Tiacci, +19

New England Journal of Medicine

The acute promyelocytic leukemia-specific PML-RARα fusion protein inhibits differentiation and promotes survival of myeloid precursor cells

F Grignani, Pier Francesco Ferrucci, Ugo Testa, +8

Cell

Hematological MalignancyMixed-phenotype Acute LeukemiaHematologyImmunologyCell Death +6

Acute promyelocytic leukemia: from genetics to treatment

F Grignani, M Fagioli, Myriam Alcalay, +6

Blood

Hematological MalignancyMixed-phenotype Acute LeukemiaMalignant Blood DisorderHematologyImmunology +3

A<i>PMLRAR</i>α transgene initiates murine acute promyelocytic leukemia

Diane E. Brown, Scott C. Kogan, Eric Lagasse, +5

Proceedings of the National Academy of Sciences

Acute promyelocytic leukemia: from genetics to treatment

F Grignani, M Fagioli, Myriam Alcalay, +6

Blood

Hematological MalignancyMixed-phenotype Acute LeukemiaMalignant Blood DisorderHematologyImmunology +3

Acute myeloid leukemia bearing cytoplasmic nucleophosmin (NPMc+ AML) shows a distinct gene expression profile characterized by up-regulation of genes involved in stem-cell maintenance

Myriam Alcalay, Enrico Tiacci, Roberta Bergomas, +14

Blood

Cell-cycle restriction limits DNA damage and maintains self-renewal of leukaemia stem cells

Andrea Viale, Francesca Franco, Annette Orleth, +11

Nature

ChromatinGenome InstabilityDna DamageMedicineLeukaemia Stem Cells +9

Structure and origin of the acute promyelocytic leukemia myl/RAR alpha cDNA and characterization of its retinoid-binding and transactivation properties.

P P Pandolfi, F Grignani, Myriam Alcalay, +3

PubMed

Genomic variability and alternative splicing generate multiple PML/RAR alpha transcripts that encode aberrant PML proteins and PML/RAR alpha isoforms in acute promyelocytic leukaemia.

Pier Paolo Pandolfi, Myriam Alcalay, M Fagioli, +7

The EMBO Journal

Hematological MalignancyGeneticsPathologyMolecular GeneticsGenomic Variability +7

Role for Histone Deacetylase 1 in Human Tumor Cell Proliferation

Silvia Senese, Katrin Zaragoza, Simone P. Minardi, +8

Molecular and Cellular Biology

Histone ModificationsMolecular RegulationEpigenetic ChangeHdac1 CellsCell Cycle +20