Analgesic effect of Anatolian propolis in mice.

Abstract

OBJECTIVES: The aim of the present study was to assess the analgesic effect of Anatolian propolis, which is added to toothpastes as a prophylactic component for periodontal diseases. METHODS: Water-, ethanol- and acetone-extracted Anatolian propolis were prepared. The analgesic effect of the extracts was assessed using the tail-flick test in mice (n=6 per extract). Comparison among groups was made using one-way ANOVA, followed by post-hoc Scheffe test to determine significant differences among the means of the data groups. P<0.05 was accepted as indicating a significant difference. RESULTS: We found that water-extracted Anatolian propolis caused a significant increase, 1.61-fold (p<0.001 versus control), in the latency time using tail-flick test in mice. However, acetone-extracted and ethanol-extracted propolis led to no significant effect. CONCLUSION: We proved the analgesic effect of water-extracted Anatolian propolis. Thus, propolis used in the composition of toothpastes may be beneficial in terms of its analgesic action in addition to its other favorable effects.