In Vitro Differentiation of Pluripotent Stem Cells into Functional β Islets Under 2D and 3D Culture Conditions and In Vivo Preclinical Validation of 3D Islets

Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors

Kazutoshi Takahashi, Koji Tanabe, Mari Ohnuki et al. · Cell · 2007 · 19.9K citations

Tissue Engineering, Regenerative Medicine, Defined Factors +14

Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells

Junying Yu, Maxim A. Vodyanik, Kim Smuga-Otto et al. · Science · 2007 · 10.2K citations

Tissue Engineering, Adult Stem Cell, Transplantation Medicine +18

Reprogramming of human somatic cells to pluripotency with defined factors

In-Hyun Park, Rui Zhao, Jason A. West et al. · Nature · 2007 · 2.8K citations

Defined Factors, Human Cell, Induced Pluripotent Stem Cell +9

Production of pancreatic hormone–expressing endocrine cells from human embryonic stem cells

Kevin A. D’Amour, Anne G. Bang, Susan Eliazer et al. · Nature Biotechnology · 2006 · 1.9K citations

Embryo Culture, Endocrine Cells, Embryonic Stem Cell +9

Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo

Evert Kroon, Laura A. Martinson, Kuniko Kadoya et al. · Nature Biotechnology · 2008 · 1.8K citations

Regenerative Medicine, Induced Pluripotent Stem Cell, Developmental Biology +8