Tramadol versus Dextropropoxyphene in the Treatment of Osteoarthritis

Opioid and nonopioid components independently contribute to the mechanism of action of tramadol, an 'atypical' opioid analgesic.

Robert B. Raffa, Elmar Friderichs, Wolfgang Reimann et al. · Journal of Pharmacology and Experimental Therapeutics · 1992 · 1.2K citations

Medicine, Pharmacology, Pharmacotherapy +17

Osteo-Arthrosis: Prevalence in the Population and Relationship between Symptoms and X-ray Changes

J. S. Lawrence, J. M. Bremner, F. Bier · Annals of the Rheumatic Diseases · 1966 · 685 citations · Full text

Medicine, Orthopaedic Surgery, Orthopedic Surgery +12

Non-steroidal anti-inflammatory drugs and life threatening complications of peptic ulceration.

C P Armstrong, A L Blower · Gut · 1987 · 631 citations · Full text

Medicine, Pharmacotherapy, Surgery +17

Comparison of an Antiinflammatory Dose of Ibuprofen, an Analgesic Dose of Ibuprofen, and Acetaminophen in the Treatment of Patients with Osteoarthritis of the Knee

John Bradley, Kenneth D. Brandt, Barry P. Katz et al. · New England Journal of Medicine · 1991 · 629 citations

Medicine, Orthopaedic Surgery, Pharmacotherapy +17

Complementary and synergistic antinociceptive interaction between the enantiomers of tramadol.

Robert B. Raffa, Elmar Friderichs, Wolfgang Reimann et al. · Journal of Pharmacology and Experimental Therapeutics · 1993 · 440 citations

Medicine, Medicinal Chemistry, Pharmacology +17