PubMed · 1994 · 18 citations · 0 references
MedicinePharmacokineticsPharmacologyPharmacodynamicsPharmacokinetic ModelingPharmacokinetic-pharmacodynamic ModelingConcentration-effect RelationshipsDose CalculationDose-response RelationshipsLinear PharmacokineticsClinical Dose OptimizationDose-dependent Pharmacokinetic ModelsDose-time RelationshipPharmacodynamic Dose SelectionPharmacokinetic Dose SelectionPharmacokinetic-pharmacodynamic Link ModelingTizanidine Therapy
The relationship among tizanidine dose, plasma concentration, and antispastic action is linear in nature. Response to a given dose of this agent varies among patients, and determining the appropriate clinical dose requires individual titration.