Concepedia

Potent benzoazepinone γ-secretase modulators with improved bioavailability

Joey L. Methot, Christian Fischer, Chaomin Li, Alexey Rivkin, Sean P. Ahearn, William C. Brown, Elizabeth H. Kelley, Dawn M. Mampreian, Adam Schell, Andrew Rosenau,

Bioorganic & Medicinal Chemistry Letters · 2015 · 13 citations · 27 references

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27

Physiochemical drug properties associated with in vivo toxicological outcomes

Jason D. Hughes, Julian Blagg, David A. Price et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 973 citations

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Lessons from a Failed γ-Secretase Alzheimer Trial

Bart De Strooper · Cell · 2014 · 273 citations · Full text

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Modulation of γ-Secretase Reduces β-Amyloid Deposition in a Transgenic Mouse Model of Alzheimer's Disease

Maria Z. Kounnas, Anne M. Danks, Soan Cheng et al. · Neuron · 2010 · 254 citations · Full text

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Differential Effects between γ-Secretase Inhibitors and Modulators on Cognitive Function in Amyloid Precursor Protein-Transgenic and Nontransgenic Mice

Yasuyuki Mitani, Junko Yarimizu, Kyoko Saita et al. · Journal of Neuroscience · 2012 · 196 citations · Full text

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Structure of a presenilin family intramembrane aspartate protease

Xiaochun Li, Shangyu Dang, Chuangye Yan et al. · Nature · 2012 · 187 citations

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