Ring systems in medicinal chemistry: A cheminformatics analysis of ring popularity in drug discovery over time

Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success

Frank Lovering, Jack Bikker, Christine Humblet · Journal of Medicinal Chemistry · 2009 · 4.4K citations

Pharmacy, Chemistry, Medicinal Chemistry +8

ZINC-22─A Free Multi-Billion-Scale Database of Tangible Compounds for Ligand Discovery

Benjamin I. Tingle, Khanh Tang, Mar Castanon et al. · Journal of Chemical Information and Modeling · 2023 · 268 citations · Full text

Pharmacy, Chemistry, Medicinal Chemistry +17

Assessing the Scaffold Diversity of Screening Libraries

Mireille Krier, Guillaume Bret, Didier Rognan · Journal of Chemical Information and Modeling · 2006 · 120 citations

Pharmacy, Chemistry, Medicinal Chemistry +17

A Highly Conserved Aspartic Acid (Asp-155) Anchors the Terminal Amine Moiety of Tryptamines and Is Involved in Membrane Targeting of the 5-HT2A Serotonin Receptor But Does Not Participate in Activation via a “Salt-Bridge Disruption” Mechanism

Kurt Kristiansen, Wesley K. Kroeze, David L. Willins et al. · Journal of Pharmacology and Experimental Therapeutics · 2000 · 117 citations

Life Sciences, Molecular Biology, Pharmacology +17

Selective Estrogen Receptor Degraders (SERDs): A Promising Strategy for Estrogen Receptor Positive Endocrine-Resistant Breast Cancer

Yunlong Lu, Wukun Liu · Journal of Medicinal Chemistry · 2020 · 102 citations · Full text

Medicine, Oncology, Pharmacology +16