Concepedia

Contrasting cytotoxic and regulatory T cell responses underlying distinct clinical outcomes to anti-PD-1 plus lenvatinib therapy in cancer

Xinyi Guo, Hu Nie, Wenwen Zhang, Jiesheng Li, Jing Ge, Bowen Xie, Wenbo Hu, Yicheng Zhu, Na Zhong, Xinmei Zhang,

Cancer Cell · 2025 · 67 citations · 111 references

Concepts

MedicineOncologyPharmacologyCancer ImmunologyImmunotherapyTumor ImmunologyAntitumor T Cell ResponsesCancer ImmunotherapyCheckpoint Inhibitor TherapyCytotoxic T Lymphocyte ResponsesImmune Checkpoint InhibitorsImmune Checkpoint RegulationLenvatinib TherapyProgrammed Cell Death Protein 1 InhibitorsProgrammed Death-1 BlockadeProgrammed Death-1 InhibitionProgrammed Death-ligand 1 InhibitionProgrammed Death-ligand 1 InhibitorsRegulatory Immune Responses

References

111

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

Michael I. Love, Wolfgang Huber, Simon Anders · Genome biology · 2014 · 100.5K citations · Full text

Life Sciences, Bioinformatics, Biostatistics +15

Integrated analysis of multimodal single-cell data

Yuhan Hao, Stephanie Hao, Erica Andersen‐Nissen et al. · Cell · 2021 · 16K citations · Full text

Life Sciences, Bioinformatics, Immunology +17

Salmon provides fast and bias-aware quantification of transcript expression

Rob Patro, Geet Duggal, Michael I. Love et al. · Nature Methods · 2017 · 13.7K citations · Full text

Life Sciences, Bioinformatics, Molecular Biology +12

clusterProfiler 4.0: A universal enrichment tool for interpreting omics data

Tianzhi Wu, Erqiang Hu, Shuangbin Xu et al. · The Innovation · 2021 · 12.7K citations · Full text

Life Sciences, Bioinformatics, Biology +13

Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer

Suzanne L. Topalian, F. Stephen Hodi, Julie R. Brahmer et al. · New England Journal of Medicine · 2012 · 12.7K citations · Full text

Life Sciences, Immunology, Oncology +17