Concepedia

Chemically engineered antibodies for autophagy-based receptor degradation

Binghua Cheng, Meiqing Li, Jiwei Zheng, Jiaming Liang, Yanyan Li, Ruijing Liang, Hui Tian, Zeyu Zhou, Li Ding, Jian Ren,

Nature Chemical Biology · 2025 · 24 citations · 27 references

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27

Lysosome-targeting chimaeras for degradation of extracellular proteins

Steven M. Banik, Kayvon Pedram, Simon Wisnovsky et al. · Nature · 2020 · 1.1K citations · Full text

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The Advantages of Targeted Protein Degradation Over Inhibition: An RTK Case Study

George M. Burslem, Blake E. Smith, Ashton C. Lai et al. · Cell chemical biology · 2017 · 673 citations · Full text

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AUTACs: Cargo-Specific Degraders Using Selective Autophagy

Daiki Takahashi, Jun Moriyama, Tomoe Y. Nakamura et al. · Molecular Cell · 2019 · 613 citations · Full text

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LYTACs that engage the asialoglycoprotein receptor for targeted protein degradation

Green Ahn, Steven M. Banik, Caitlyn L. Miller et al. · Nature Chemical Biology · 2021 · 581 citations · Full text

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Allele-selective lowering of mutant HTT protein by HTT–LC3 linker compounds

Zhaoyang Li, Cen Wang, Ziying Wang et al. · Nature · 2019 · 521 citations · Full text

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