Concepedia

Receptor Degradation

Receptor Degradation is a regulatory process within receptor tyrosine kinase signaling pathways whereby activated cell surface receptors are internalized and targeted for proteolytic destruction, primarily through the ubiquitin-proteasome system or lysosomal pathways, to attenuate downstream signal transduction.

530

Publications

43K

Citations

2.6K

Authors

684

Institutions

Publications per year

2017–2026

71

Parents

Publications

530

Smurf1 Interacts with Transforming Growth Factor-β Type I Receptor through Smad7 and Induces Receptor Degradation

Takanori Ebisawa, Minoru Fukuchi, Gyo Murakami et al. · Journal of Biological Chemistry · 2001 · 841 citations · Full text

, , +9

Regulation of Receptor Fate by Ubiquitination of Activated β <sub>2</sub> -Adrenergic Receptor and β-Arrestin

Sudha K. Shenoy, Patricia McDonald, Trudy A. Kohout et al. · Science · 2001 · 813 citations · Full text

, , +16

Binding of Proprotein Convertase Subtilisin/Kexin Type 9 to Epidermal Growth Factor-like Repeat A of Low Density Lipoprotein Receptor Decreases Receptor Recycling and Increases Degradation

Dawei Zhang, Thomas A. Lagace, Rita Garuti et al. · Journal of Biological Chemistry · 2007 · 784 citations · Full text

, , +17

LYTACs that engage the asialoglycoprotein receptor for targeted protein degradation

Green Ahn, Steven M. Banik, Caitlyn L. Miller et al. · Nature Chemical Biology · 2021 · 581 citations · Full text

, , +13

All ErbB Receptors Other Than the Epidermal Growth Factor Receptor Are Endocytosis Impaired

Josep Baulida, Matthias H. Kraus, Maurizio Alimandi et al. · Journal of Biological Chemistry · 1996 · 451 citations · Full text

, , +15

1–5 of 530

Authors

2.6K

  1. GC
    Graham Carpenter

    Vanderbilt University, United States

    7 publications · 987 citations

    7

    h-index

  2. HB
    Hamid Band

    University of Nebraska Medical Center, United States

    6 publications · 697 citations

    6

    h-index

  3. YY
    Yosef Yarden

    Weizmann Institute of Science, Israel

    6 publications · 1.1K citations

    6

    h-index

  4. FM
    Federico Mayor

    Universidad Autónoma de Madrid, Spain

    6 publications · 530 citations

    6

    h-index

  5. RS
    Richard S. Pollenz

    University of South Florida, United States

    5 publications · 426 citations

    5

    h-index

1–5 of 2.6K

Institutions

684

  1. Harvard University

    Cambridge, United States

    20 h-index

    100 publications

    14K citations

  2. National Institutes of Health

    Bethesda, United States

    17 h-index

    75 publications

    8.8K citations

  3. University of California San Diego

    San Diego, United States

    16 h-index

    57 publications

    4.7K citations

  4. Weizmann Institute of Science

    Rehovot, Israel

    15 h-index

    73 publications

    11.4K citations

  5. University of California, San Francisco

    San Francisco, United States

    14 h-index

    55 publications

    4.1K citations

  6. Inserm

    Paris, France

    12 h-index

    60 publications

    3.6K citations

  7. Vanderbilt University

    Nashville, United States

    12 h-index

    31 publications

    4.1K citations

  8. Centre National de la Recherche Scientifique

    Paris, France

    12 h-index

    42 publications

    1.6K citations

1–8 of 684

Venues

  1. Journal of Biological Chemistry

    JBC · 121 publications · 12.4K citations

    64

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 26 publications · 3.3K citations

    23

    h-index

  3. Molecular and Cellular Biology

    MCB · 17 publications · 2.3K citations

    17

    h-index

  4. Biochemical Journal

    BJ · 11 publications · 606 citations

    11

    h-index

  5. The Journal of Cell Biology

    JCB · 11 publications · 1.5K citations

    11

    h-index

1–5