Concepedia

The cGAS-STING pathway activates transcription factor TFEB to stimulate lysosome biogenesis and pathogen clearance

Yinfeng Xu, Qian Wang, Jun Wang, Chuying Qian, Yusha Wang, Sheng Lu, Lijiang Song, Zhengfu He, Wei Liu, Wei Wan

Immunity · 2024 · 80 citations · 70 references

DOI

Concepts

References

70

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

The EMBO Journal · 2000 · 6.5K citations · Full text

, , +11

p62/SQSTM1 Binds Directly to Atg8/LC3 to Facilitate Degradation of Ubiquitinated Protein Aggregates by Autophagy

Serhiy Pankiv, Terje Høyvarde Clausen, Trond Lamark et al. · Journal of Biological Chemistry · 2007 · 4.5K citations · Full text

, , +17

TFEB Links Autophagy to Lysosomal Biogenesis

Carmine Settembre, Chiara Di Malta, Vinicia Assunta Polito et al. · Science · 2011 · 3.3K citations

, , +17

A Gene Network Regulating Lysosomal Biogenesis and Function

Marco Sardiello, Michela Palmieri, Alberto di Ronza et al. · Science · 2009 · 2.5K citations

, , +17

A lysosome‐to‐nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

Carmine Settembre, Roberto Zoncu, Diego L. Medina et al. · The EMBO Journal · 2012 · 1.9K citations · Full text

, , +12