Concepedia

PROTAC-mediated FTO protein degradation effectively alleviates diet-induced obesity and hepatic steatosis

Yang Xiao, Tianyu Jiang, Xinyi Qi, Jinfeng Zhou, Tingli Pan, Qichao Liao, Siqi Liu, Hao Zhang, Jiale Wang, Xinzhen Yang,

International Journal of Biological Macromolecules · 2024 · 10 citations · 24 references

DOI

Concepts

References

24

A Common Variant in the <i>FTO</i> Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity

Timothy M. Frayling, Nicholas J. Timpson, Michael N. Weedon et al. · Science · 2007 · 4.5K citations · Full text

, , +17

The Obesity-Associated <i>FTO</i> Gene Encodes a 2-Oxoglutarate-Dependent Nucleic Acid Demethylase

Thomas Gerken, Christophe A. Girard, Yi‐Chun Loraine Tung et al. · Science · 2007 · 1.5K citations · Full text

, , +9

<i>FTO</i> Obesity Variant Circuitry and Adipocyte Browning in Humans

Melina Claussnitzer, Simon N. Dankel, Kyoung-Han Kim et al. · New England Journal of Medicine · 2015 · 1.4K citations · Full text

, , +15

The global burden of metabolic disease: Data from 2000 to 2019

Nicholas Chew, Cheng Han Ng, Darren Jun Hao Tan et al. · Cell Metabolism · 2023 · 764 citations

, , +14

Overexpression of Fto leads to increased food intake and results in obesity

Chris Church, Lee Moir, Fiona McMurray et al. · Nature Genetics · 2010 · 721 citations · Full text

, , +9