Oxygen-boosted fluorinated prodrug hybrid nanoassemblies for bidirectional amplification of breast cancer ferroptosis

Nanocatalytic Theranostics with Glutathione Depletion and Enhanced Reactive Oxygen Species Generation for Efficient Cancer Therapy

Lian‐Hua Fu, Yilin Wan, Chao Qi et al. · Advanced Materials · 2021 · 810 citations

Pharmacy, Oncology, Pharmacology +17

Cystine transporter regulation of pentose phosphate pathway dependency and disulfide stress exposes a targetable metabolic vulnerability in cancer

Xiaoguang Liu, Kellen Olszewski, Yilei Zhang et al. · Nature Cell Biology · 2020 · 595 citations · Full text

Life Sciences, Biochemistry, Cancer Biology +17

Trisulfide bond–mediated doxorubicin dimeric prodrug nanoassemblies with high drug loading, high self-assembly stability, and high tumor selectivity

Yinxian Yang, Bingjun Sun, Shiyi Zuo et al. · Science Advances · 2020 · 298 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmaceutics +17

Activatable nanomedicine for overcoming hypoxia-induced resistance to chemotherapy and inhibiting tumor growth by inducing collaborative apoptosis and ferroptosis in solid tumors

Jingke Fu, Tao Li, Yangzi Yang et al. · Biomaterials · 2020 · 233 citations

Medicine, Oncology, Pharmacology +17

HIF-1α drives resistance to ferroptosis in solid tumors by promoting lactate production and activating SLC1A1

Zhou Yang, Wei Su, Xiyi Wei et al. · Cell Reports · 2023 · 209 citations · Full text

Medicine, Cancer Biology, Oncology +17