Concepedia

YTHDC1 is a therapeutic target for B-cell acute lymphoblastic leukemia by attenuating DNA damage response through the KMT2C-H3K4me1/me3 epigenetic axis

Xinxin Li, Minhua Zheng, Shoubao Ma, Fengze Nie, Zhiqiang Yin, Yanan Liang, Xianchun Yan, Weihong Wen, Jianhua Yu, Yingmin Liang,

Leukemia · 2024 · 18 citations · 31 references

DOI

Concepts

References

31

Efficacy and Toxicity Management of 19-28z CAR T Cell Therapy in B Cell Acute Lymphoblastic Leukemia

Marco L. Davila, Isabelle Rivière, Xiuyan Wang et al. · Science Translational Medicine · 2014 · 2.5K citations · Full text

, , +17

Nuclear m6A Reader YTHDC1 Regulates mRNA Splicing

Wen Xiao, Samir Adhikari, Ujwal Dahal et al. · Molecular Cell · 2016 · 2.1K citations · Full text

, , +10

YTHDC1 mediates nuclear export of N6-methyladenosine methylated mRNAs

Ian A. Roundtree, Guan‐Zheng Luo, Zijie Zhang et al. · eLife · 2017 · 1.2K citations · Full text

, , +16

Potent inhibition of DOT1L as treatment of MLL-fusion leukemia

Scott R. Daigle, Edward J. Olhava, Carly A. Therkelsen et al. · Blood · 2013 · 725 citations · Full text

, , +11

Structural basis for selective binding of m6A RNA by the YTHDC1 YTH domain

Chao Xu, Xiao Wang, Ke Liu et al. · Nature Chemical Biology · 2014 · 708 citations

, , +17