Concepedia

Local TSH/TSHR signaling promotes CD8 <sup>+</sup> T cell exhaustion and immune evasion in colorectal carcinoma

Sisi Zeng, Huiling Hu, Zhiyang Li, Qi Hu, Rong Shen, Mingzhou Li, Yunshi Liang, Zuokang Mao, Yandong Zhang, Wanqi Zhan,

Cancer Communications · 2024 · 20 citations · 22 references

DOIFull text

Open access

Abstract

The present findings highlighted the role of endogenous TSH/TSHR signaling in CD8<sup>+</sup> T cell exhaustion and immune evasion in CRC. TSHR may be suitable as a predictive and therapeutic biomarker in CRC immunotherapy.

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