Concepedia

Intercellular nanotube-mediated mitochondrial transfer enhances T cell metabolic fitness and antitumor efficacy

Jeremy Baldwin, Christoph Heuser, Tanmoy Saha, Roland Christian Schelker, Dragana Slavkovic‐Lukic, Nicholas Strieder, Inmaculada Hernandez-Lopez, Nisha Rana, Markus Barden, Fabio Mastrogiovanni,

Cell · 2024 · 204 citations · 58 references

DOIFull text

Open access

Concepts

Abstract

T cells mediated superior antitumor responses, prolonging animal survival. These findings establish intercellular mitochondrial transfer as a prototype of organelle medicine, opening avenues to next-generation cell therapies.

References

58

Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage

Dvir Aran, Agnieszka Looney, Leqian Liu et al. · Nature Immunology · 2019 · 5.3K citations

, , +10

Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy

Se Jin Im, Masao Hashimoto, Michael Y. Gerner et al. · Nature · 2016 · 2.1K citations · Full text

, , +16

FlowSOM: Using self‐organizing maps for visualization and interpretation of cytometry data

Sofie Van Gassen, Britt Callebaut, Mary J. van Helden et al. · Cytometry Part A · 2015 · 2.1K citations

, , +12

Nanotubular Highways for Intercellular Organelle Transport

Amin Rustom, Rainer Saffrich, Ivanka Marković et al. · Science · 2004 · 2K citations

, , +17

Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia

Joseph A. Fraietta, Simon F. Lacey, Elena J. Orlando et al. · Nature Medicine · 2018 · 1.8K citations · Full text

, , +16