Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy

Se Jin Im, Masao Hashimoto, Michael Y. Gerner, +13

Nature

Pd-1 TherapyCancer ImmunosurveillanceAutoimmune DiseaseMedicineImmunology +9

An intra-tumoral niche maintains and differentiates stem-like CD8 T cells

Caroline S. Jansen, Nataliya Prokhnevska, Viraj A. Master, +25

Nature

Lineage PlasticityMedicineIntra-tumoral Niche MaintainsT-regulatory CellImmunology +6

Proliferating Transitory T Cells with an Effector-like Transcriptional Signature Emerge from PD-1+ Stem-like CD8+ T Cells during Chronic Infection

William Henry Hudson, Julia Gensheimer, Masao Hashimoto, +10

Immunity

InflammationAutoimmune DiseaseAdaptive Immune SystemTransitory T CellsT-regulatory Cell +9

Functional HPV-specific PD-1+ stem-like CD8 T cells in head and neck cancer

Christiane S. Eberhardt, Haydn Kissick, Mihir R. Patel, +15

Nature

Neck CancerCancer ImmunosurveillanceImmunologyHead And Neck CancerHead And Neck Squamous Cell Carcinoma +8

PD-1 combination therapy with IL-2 modifies CD8+ T cell exhaustion program

Masao Hashimoto, Koichi Araki, Maria A. Cardenas, +28

Nature

Autoimmune DiseaseT-regulatory CellImmunologyImmune RegulationPd-1 Combination Therapy +6

Epigenetic signature of PD-1+ TCF1+ CD8 T cells that act as resource cells during chronic viral infection and respond to PD-1 blockade

Rohit R. Jadhav, Se Jin Im, Bin Hu, +7

Proceedings of the National Academy of Sciences

Tumor-draining lymph node is important for a robust abscopal effect stimulated by radiotherapy

Zachary S. Buchwald, Tahseen H. Nasti, Judong Lee, +7

Journal for ImmunoTherapy of Cancer

PD-1+ stemlike CD8 T cells are resident in lymphoid tissues during persistent LCMV infection

Se Jin Im, Bogumila T. Konieczny, William Henry Hudson, +2

Proceedings of the National Academy of Sciences

Crucial Roles of Interleukin-7 in the Development of T Follicular Helper Cells and in the Induction of Humoral Immunity

Yong Bok Seo, Se Jin Im, Hong Namkoong, +12

Journal of Virology

PD-1 blockade increases the self-renewal of stem-like CD8 T cells to compensate for their accelerated differentiation into effectors

Amanda L. Gill, Peter H. Wang, Judong Lee, +12

Science Immunology