Pharmacological inhibition of cGAS ameliorates postoperative cognitive dysfunction by suppressing caspase-3/GSDME-dependent pyroptosis

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

Yupeng Wang, Wenqing Gao, Xuyan Shi et al. · Nature · 2017 · 3.2K citations

Life Sciences, Cell Biology, Oncology +13

A survey of human brain transcriptome diversity at the single cell level

Spyros Darmanis, Steven A. Sloan, Ye Zhang et al. · Proceedings of the National Academy of Sciences · 2015 · 1.6K citations · Full text

Life Sciences, Neurobiology, Neuroscience +17

Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis

Melanie Fritsch, Saskia Diana Günther, Robin Schwarzer et al. · Nature · 2019 · 1.1K citations

Life Sciences, Cell Biology, Molecular Biology +11

Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice

Jessica Vincent, Carolina Adura, Pu Gao et al. · Nature Communications · 2017 · 372 citations · Full text

Life Sciences, Immunology, Molecular Biology +17

Inhibition of double‐strand DNA‐sensing cGAS ameliorates brain injury after ischemic stroke

Qian Li, Yuze Cao, Chun Dang et al. · EMBO Molecular Medicine · 2020 · 289 citations · Full text

Medicine, Neurology, Neuroscience +15