Elevated type I IFN signalling directly affects CD8+ T-cell distribution and autoantigen recognition of the skeletal muscles in active JDM patients

Type I interferons act directly on CD8 T cells to allow clonal expansion and memory formation in response to viral infection

Ganesh Kolumam, Sunil Thomas, Lucas Thompson et al. · The Journal of Experimental Medicine · 2005 · 950 citations · Full text

Veterinary Medicine, Immunology, Infectious Diseases +17

Rituximab in the treatment of refractory adult and juvenile dermatomyositis and adult polymyositis: A randomized, placebo‐phase trial

Chester V. Oddis, Ann M. Reed, Rohit Aggarwal et al. · Arthritis & Rheumatism · 2012 · 691 citations

Medicine, Immunology, Pharmacotherapy +14

A critical function for type I interferons in cancer immunoediting

Gavin P. Dunn, Allen T. Bruce, Kathleen C. F. Sheehan et al. · Nature Immunology · 2005 · 597 citations

Medicine, Immunology, Oncology +14

Conditional up-regulation of MHC class I in skeletal muscle leads to self-sustaining autoimmune myositis and myositis-specific autoantibodies

Kanneboyina Nagaraju, Nina Raben, Lisa Loeffler et al. · Proceedings of the National Academy of Sciences · 2000 · 314 citations

Life Sciences, Immunology, Pathology +17

Prednisone versus prednisone plus ciclosporin versus prednisone plus methotrexate in new-onset juvenile dermatomyositis: a randomised trial

Nicolino Ruperto, Angela Pistorio, Sheila Oliveira et al. · The Lancet · 2015 · 232 citations

Medicine, Dermatology, Pediatrics +15