Lactate and lactylation: Behind the development of tumors

Control of Regulatory T Cell Development by the Transcription Factor <i>Foxp3</i>

Shohei Hori, Takashi Nomura, Shimon Sakaguchi · Science · 2003 · 8K citations

Lymphocyte Development, Genetics, T-regulatory Cell +24

Metabolic regulation of gene expression by histone lactylation

Di Zhang, Zhanyun Tang, He Huang et al. · Nature · 2019 · 3.5K citations · Full text

Histone Modifications, Chromatin, Chromatin Remodeling +7

Functional polarization of tumour-associated macrophages by tumour-derived lactic acid

Oscar R. Colegio, Ngoc-Quynh Chu, Alison L. Szabo et al. · Nature · 2014 · 2.8K citations · Full text

Inflammation, Lacrimal Gland, Immunology +6

The cellular and molecular origin of tumor-associated macrophages

Ruth A. Franklin, Will Liao, Abira Sarkar et al. · Science · 2014 · 1.4K citations · Full text

Metabolic support of tumour-infiltrating regulatory T cells by lactic acid

McLane J. Watson, Paolo Vignali, Steven J. Mullett et al. · Nature · 2021 · 1.1K citations · Full text

Cancer Immunosurveillance, T-regulatory Cell, Immunology +6