Concepedia

EPA and DHA differentially improve insulin resistance by reducing adipose tissue inflammation—targeting GPR120/PPARγ pathway

Xian Yang, Xudong Li, Manjiang Hu, Jie Huang, Siyan Yu, Huanting Zeng, Limei Mao

The Journal of Nutritional Biochemistry · 2024 · 36 citations · 30 references

DOI

Concepts

References

30

GPR120 Is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-inflammatory and Insulin-Sensitizing Effects

Da Young Oh, Saswata Talukdar, Eun Ju Bae et al. · Cell · 2010 · 2.4K citations · Full text

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Omega-3 Fatty Acids Prevent Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome Activation

Yiqing Yan, Wei Jiang, Thibaud Spinetti et al. · Immunity · 2013 · 756 citations · Full text

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A Gpr120-selective agonist improves insulin resistance and chronic inflammation in obese mice

Da Young Oh, Evelyn Walenta, Taro E. Akiyama et al. · Nature Medicine · 2014 · 389 citations · Full text

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Global characterization of macrophage polarization mechanisms and identification of M2-type polarization inhibitors

Lizhi He, Jhih-Hua Jhong, Qi Chen et al. · Cell Reports · 2021 · 349 citations · Full text

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Omega-3 Fatty Acids Activate Ciliary FFAR4 to Control Adipogenesis

Keren I. Hilgendorf, Carl T. Johnson, Anja Mezger et al. · Cell · 2019 · 262 citations · Full text

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