Concepedia

Construction of Isoquinolone Scaffolds on DNA via Rhodium(III)-Catalyzed C–H Activation

Yusong Ye, Madeline Berry, William J. Bock, Kunpeng Cheng, Sajiv K. Nair, Christiana S. Park, Ryan L. Patman, Sylvie K. Sakata, Michelle Tran‐Dubé, Joyann S. Donaldson,

Organic Letters · 2024 · 15 citations · 33 references

DOI

Concepts

Abstract

Isoquinolone is one of the most common heterocyclic core structures in countless natural products and many bioactive compounds. Here, a highly efficient approach to synthesize isoquinolone scaffolds on DNA via rhodium(III)-catalyzed C-H activation has been described. This chemistry transformation is robust and has shown good compatibility with DNA, which is suitable for DNA-encoded library synthesis.

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