The intestinal epithelial-macrophage-crypt stem cell axis plays a crucial role in regulating and maintaining intestinal homeostasis

Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

Toshiro Sato, Johan H. van Es, Hugo J.G. Snippert et al. · Nature · 2010 · 2.4K citations

Lgr5 Stem Cells, Cell Lineage, Developmental Biology +8

Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine V. Unitarian theory of the origin of the four epithelial cell types

Hazel Cheng, C. P. Leblond · American Journal of Anatomy · 1974 · 1.7K citations

Immunology, Immune Regulation, Pathology +21

Identification of ZO-1: a high molecular weight polypeptide associated with the tight junction (zonula occludens) in a variety of epithelia.

Bruce R. Stevenson, Janet D. Siliciano, Mark S. Mooseker et al. · The Journal of Cell Biology · 1986 · 1.6K citations · Full text

Protein Secretion, Immunocytochemical Technique, Laboratory Immunology +23

BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt–β-catenin signaling

Xi He, Jiwang Zhang, Wei-Gang Tong et al. · Nature Genetics · 2004 · 1K citations · Full text

Developmental Biology, Tissue Development, Signaling Pathway +7

A mitochondrial specific stress response in mammalian cells

Quan Zhao · The EMBO Journal · 2002 · 999 citations · Full text

Mitochondrial Biogenesis, Mitochondrial Function, Medicine +5