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Tumor Cell–Intrinsic p38 MAPK Signaling Promotes IL1α-Mediated Stromal Inflammation and Therapeutic Resistance in Pancreatic Cancer

DOIFull Paper Access

32

Citations

34

References

2024

Year

Samara P. Singh, Austin R. Dosch, Siddharth Mehra, Iago De Castro Silva, Anna Bianchi, Vanessa T. Garrido, Zhiqun Zhou, Andrew Adams, Haleh Amirian, Edmond W. Box,
Cancer Research

Abstract

Inhibition of p38 MAPK suppresses tumor cell-derived IL1α and attenuates the inflammatory stroma and immunosuppressive tumor microenvironment to overcome chemotherapeutic resistance in pancreatic cancer.

References

YearCitations

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