A label-free electrochemical sensor for the detection of two kinds of targets based on CRISPR/Cas12a system

CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity

Janice S. Chen, Enbo Ma, Lucas B. Harrington et al. · Science · 2018 · 4.4K citations

Life Sciences, Genetics, Molecular Biology +13

Applications of CRISPR technologies in research and beyond

Rodolphe Barrangou, Jennifer A. Doudna · Nature Biotechnology · 2016 · 1K citations

Life Sciences, Genetics, Molecular Biology +12

Carboxylic Carbon Quantum Dots as a Fluorescent Sensing Platform for DNA Detection

Adeline Huiling Loo, Zdeněk Sofer, Daniel Bouša et al. · ACS Applied Materials & Interfaces · 2016 · 321 citations

Engineering, Bioengineering, Biotechnology +17

CRISPR/Cas12a-Mediated Interfacial Cleaving of Hairpin DNA Reporter for Electrochemical Nucleic Acid Sensing

Decai Zhang, Yurong Yan, Haiying Que et al. · ACS Sensors · 2020 · 228 citations

Engineering, Biotechnology, Molecular Biology +17

Porphyrin-Encapsulated Metal–Organic Frameworks as Mimetic Catalysts for Electrochemical DNA Sensing via Allosteric Switch of Hairpin DNA

Pinghua Ling, Jianping Lei, Lei Zhang et al. · Analytical Chemistry · 2015 · 222 citations

Engineering, Biotechnology, Chemistry +17