Predisposal of Interferon Regulatory Factor 1 Deficiency to Accumulate <scp>DNA</scp> Damage and Promote Osteoarthritis Development in Cartilage

Abstract

IRF1 offers DNA damage surveillance in chondrocytes, protecting them from oxidative stress associated with OA risk factors. Our study provides a crucial and cautionary perspective that compromising IRF1 activity renders chondrocytes vulnerable to cellular senescence and promotes OA development.