A digital platform for One-Pot signal enhanced foodborne pathogen detection based on mesophilic argonaute-driven polydisperse microdroplet reactors and machine learning

CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity

Janice S. Chen, Enbo Ma, Lucas B. Harrington et al. · Science · 2018 · 4.1K citations

Ssdna Molecules, Molecular Diagnostic Techniques, Engineering +14

Nucleic acid detection with CRISPR-Cas13a/C2c2

Jonathan S. Gootenberg, Omar O. Abudayyeh, Jeong Wook Lee et al. · Science · 2017 · 3.6K citations · Full text

Cas12aVDet: A CRISPR/Cas12a-Based Platform for Rapid and Visual Nucleic Acid Detection

Bei Wang, Rui Wang, Daqi Wang et al. · Analytical Chemistry · 2019 · 424 citations

Aerosol Contamination, Engineering, Molecular Biology +17

Fast and sensitive detection of SARS-CoV-2 RNA using suboptimal protospacer adjacent motifs for Cas12a

Shuhan Lu, Xiaohan Tong, Yang Han et al. · Nature Biomedical Engineering · 2022 · 327 citations · Full text

Sensitive Detection, Viral Diagnostics, Rna Structure Prediction +8

opvCRISPR: One-pot visual RT-LAMP-CRISPR platform for SARS-cov-2 detection

Rui Wang, Chunyan Qian, Yanan Pang et al. · Biosensors and Bioelectronics · 2020 · 325 citations · Full text

Viral Diagnostics, Virology, Medicine +3