HDAC-targeting epigenetic modulators for cancer immunotherapy

Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases

Ying-Nan P. Chen, Matthew J. LaMarche, Ho Man Chan et al. · Nature · 2016 · 929 citations

Life Sciences, Cell Biology, Oncology +16

Structure of HDAC3 bound to co-repressor and inositol tetraphosphate

Peter J. Watson, Louise Fairall, Guilherme Santos et al. · Nature · 2012 · 503 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +11

The PD-1/PD-L1 complex resembles the antigen-binding Fv domains of antibodies and T cell receptors

David Yin-wei Lin, Yoshimasa Tanaka, Masashi Iwasaki et al. · Proceedings of the National Academy of Sciences · 2008 · 457 citations · Full text

Life Sciences, Immunology, Molecular Biology +17

Five-Year Survival Outcomes With Nivolumab Plus Ipilimumab Versus Chemotherapy as First-Line Treatment for Metastatic Non–Small-Cell Lung Cancer in CheckMate 227

Julie R. Brahmer, Jong-Seok Lee, Tudor–Eliade Ciuleanu et al. · Journal of Clinical Oncology · 2022 · 381 citations · Full text

Medicine, Oncology, Pharmacology +17

Structural and Functional Analysis of the Human HDAC4 Catalytic Domain Reveals a Regulatory Structural Zinc-binding Domain

Matthew J. Bottomley, Paola Lo Surdo, Paolo Di Giovine et al. · Journal of Biological Chemistry · 2008 · 309 citations · Full text

Life Sciences, Molecular Biology, Enzymology +13