Brazilin-7-acetate, a novel potential drug of Parkinson's disease, hinders the formation of α-synuclein fibril, mitigates cytotoxicity, and decreases oxidative stress

An Essay on the Shaking Palsy

James Parkinson · Journal of Neuropsychiatry · 2002 · 1.3K citations · Full text

Medicine, Neurology, Psychiatry +8

EGCG remodels mature α-synuclein and amyloid-β fibrils and reduces cellular toxicity

Jan Bieschke, Jenny Russ, Ralf P. Friedrich et al. · Proceedings of the National Academy of Sciences · 2010 · 1K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Fibrils Formed in Vitro from α-Synuclein and Two Mutant Forms Linked to Parkinson's Disease are Typical Amyloid

Kelly A. Conway, James D. Harper, Peter T. Lansbury · Biochemistry · 2000 · 786 citations

Life Sciences, Neurology, Neuroscience +17

α-Synuclein binds to TOM20 and inhibits mitochondrial protein import in Parkinson’s disease

Roberto Di Maio, Paul J. Barrett, Eric K. Hoffman et al. · Science Translational Medicine · 2016 · 607 citations

Life Sciences, Molecular Biology, Neuroscience +14

Increased Protein Oxidation in Human Substantia Nigra Pars Compacta in Comparison with Basal Ganglia and Prefrontal Cortex Measured with an Improved Dinitrophenylhydrazine Assay

Erik Floor, Mary G. Wetzel · Journal of Neurochemistry · 1998 · 450 citations · Full text

Life Sciences, Neurobiology, Neuroscience +17