Concepedia

The potential of patient-derived organoids in precision medicine of biliary tract cancer

Mariana Yáñez-Bartolomé, Teresa Macarulla, Tian V. Tian

Cell Reports Medicine · 2023 · 10 citations · 7 references

DOIFull text

Open access

Concepts

Abstract

Chemotherapy resistance in biliary tract cancer (BTC) presents a major clinical hurdle. Ren et al. 1 developed and characterized an extensive collection of BTC patient-derived organoid (PDO) models, enabling advanced investigation of chemotherapy response prediction.

References

7

Human primary liver cancer–derived organoid cultures for disease modeling and drug screening

Laura Broutier, Gianmarco Mastrogiovanni, Monique M.A. Verstegen et al. · Nature Medicine · 2017 · 1.5K citations · Full text

, , +17

Biliary tract cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up

Arndt Vogel, John Bridgewater, Julien Edeline et al. · Annals of Oncology · 2022 · 633 citations · Full text

, , +14

Establishment of Patient-Derived Organoids and Drug Screening for Biliary Tract Carcinoma

Yoshimasa Saito, Toshihide Muramatsu, Yae Kanai et al. · Cell Reports · 2019 · 232 citations · Full text

, , +16

Personalized drug screening in patient-derived organoids of biliary tract cancer and its clinical application

Xiaoxue Ren, Mingle Huang, Weixiang Weng et al. · Cell Reports Medicine · 2023 · 46 citations · Full text

, , +17

Integrative analysis of multiple genomic data from intrahepatic cholangiocarcinoma organoids enables tumor subtyping

Hee Seung Lee, Dai Hoon Han, Kyungjoo Cho et al. · Nature Communications · 2023 · 33 citations · Full text

, , +17