CRISPR-Cas14a with competitive isothermal amplification for rapid visual pathogen diagnosis

A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity

Martin Jínek, Krzysztof Chylinski, Ines Fonfara et al. · Science · 2012 · 16.7K citations · Full text

Crispr Rnas, Adaptive Bacterial Immunity, Crispr-associated Protein Cas9 +15

RNA-Guided Human Genome Engineering via Cas9

Prashant Mali, Luhan Yang, Kevin M. Esvelt et al. · Science · 2013 · 9.2K citations · Full text

Engineering, Genetics, Molecular Biology +16

Loop-mediated isothermal amplification of DNA

Tsugunori Notomi · Nucleic Acids Research · 2000 · 8.5K citations · Full text

Isothermal Conditions, Engineering, Natural Sciences +12

CRISPR Provides Acquired Resistance Against Viruses in Prokaryotes

Rodolphe Barrangou, Christophe Fremaux, Hélène Deveau et al. · Science · 2007 · 6.2K citations

Phage-resistance Phenotype, Genetics, Bacteriophage +12

CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity

Janice S. Chen, Enbo Ma, Lucas B. Harrington et al. · Science · 2018 · 4.1K citations

Ssdna Molecules, Molecular Diagnostic Techniques, Engineering +14