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Endothelial YAP Mediates Hyperglycemia-Induced Platelet Hyperactivity and Arterial Thrombosis

DOI

24

Citations

48

References

2023

Year

Zhiyu Li, Jiachen Zhang, Zejun Ma, Guobing Zhao, Xue He, Xuefang Yu, Qiang Fu, Naishi Wu, Zhongren Ding, Haipeng Sun,
Arteriosclerosis Thrombosis and Vascular Biology

Abstract

Collectively, our data suggest that hyperglycemia-induced endothelial YAP activation aggravates platelet activation and arterial thrombus formation via PGE<sub>2</sub>/EP3 signaling. Targeting EP3 with DG-041 might be therapeutic for diabetes-related thrombosis.

References

YearCitations

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