Chemical Science · 2023 · 89 citations · 33 references
PharmacyChemistryMedicinal ChemistryBioisosterismOrganic ChemistrySynthetic Medicinal ChemistryAromatic BioisosteresHeterocycle SynthesisHeterocyclic ChemistryHeterocyclic CompoundsRing BioisosterismSteroid StructureBicyclic BioisosteresBicyclononyne ChemistryHeterocycle BioisosterismHeterocyclic Medicinal ChemistryMedicinal Heterocycles
-substituted benzene ring. The incorporation of the 1,2-disubstituted bicyclo[2.1.1]hexane core into the structure of fungicides boscalid (BASF), bixafen (Bayer CS), and fluxapyroxad (BASF) gave saturated patent-free analogs with high antifungal activity.
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Intermolecular [2π+2σ]-photocycloaddition enabled by triplet energy transfer
Roman Kleinmans, Tobias Pinkert, Subhabrata Dutta et al. · Nature · 2022 · 422 citations
A catalytic alkene insertion approach to bicyclo[2.1.1]hexane bioisosteres
Soumitra Agasti, Frédéric Beltran, Emma Pye et al. · Nature Chemistry · 2023 · 306 citations · Full text
Synthesis of meta-substituted arene bioisosteres from [3.1.1]propellane
Nils Frank, Jeremy Nugent, Bethany R. Shire et al. · Nature · 2022 · 224 citations · Full text