Concepedia

CRISPR/Cas13a-Assisted accurate and portable hepatitis D virus RNA detection

Yuan Tian, Zihao Fan, Xiangying Zhang, Ling Xu, Yaling Cao, Zhenzhen Pan, Yinkang Mo, Yao Gao, Sujun Zheng, Jing Huang,

Emerging Microbes & Infections · 2023 · 39 citations · 22 references

DOIFull text

Open access

Abstract

We developed a highly sensitive and specific, as well as a portable and easy CRISPR-based assay for the detection of HDV RNA, which could be a prospective measure for monitoring the development of HDV infection and evaluating the therapeutic effect.

References

22

CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity

Janice S. Chen, Enbo Ma, Lucas B. Harrington et al. · Science · 2018 · 4.1K citations

, , +14

Nucleic acid detection with CRISPR-Cas13a/C2c2

Jonathan S. Gootenberg, Omar O. Abudayyeh, Jeong Wook Lee et al. · Science · 2017 · 3.6K citations · Full text

Massively multiplexed nucleic acid detection with Cas13

Cheri M. Ackerman, Cameron Myhrvold, Sri Gowtham Thakku et al. · Nature · 2020 · 771 citations · Full text

Multiplexed CRISPR-based microfluidic platform for clinical testing of respiratory viruses and identification of SARS-CoV-2 variants

Nicole L. Welch, Meilin Zhu, Catherine Hua et al. · Nature Medicine · 2022 · 281 citations · Full text

, , +18

Eighth Major Clade for Hepatitis Delta Virus

Frédéric Le Gal, Elyanne Gault, Marie–Pierre Ripault et al. · Emerging infectious diseases · 2006 · 202 citations · Full text

, , +13