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Pharmacokinetic Models Scaled Up from Humanized Liver Mouse Data Can Account for Drug Monitoring Results of Atomoxetine and Its 4-Hydroxylated and N-Demethylated Metabolites in Pediatric Patients Genotyped for Cytochrome P450 2D6

Makiko Shimizu, Shotaro Uehara, Katsuhiro Ohyama, Haruka Nishimura, Yoïchi Tanaka, Yoshiro Saito, Hiroshi Suemizu, Sayaka Yoshida, Hiroshi Yamazaki

Drug Metabolism and Disposition · 2023 · 11 citations · 33 references

Open access

References

33

The CYP2D6 Activity Score: Translating Genotype Information into a Qualitative Measure of Phenotype

Andrea Gaedigk, S.D. Simon, R PEARCE et al. · Clinical Pharmacology & Therapeutics · 2007 · 793 citations

Medicine, Pharmacokinetics, Pharmacology +16

Apparent Mechanism-based Inhibition of Human CYP2D6 in Vitro by Paroxetine: Comparison with Fluoxetine and Quinidine

Kirk Bertelsen, Karthik Venkatakrishnan, Lisa L. von Moltke et al. · Drug Metabolism and Disposition · 2003 · 276 citations

Medicine, Pharmacokinetics, Pharmacology +17

Roles of NADPH-P450 Reductase and Apo- and Holo-Cytochrome b5 on Xenobiotic Oxidations Catalyzed by 12 Recombinant Human Cytochrome P450s Expressed in Membranes of Escherichia coli

Hiroshi Yamazaki, Mami Nakamura, Tomoko Komatsu et al. · Protein Expression and Purification · 2002 · 233 citations

Life Sciences, Biochemistry, Molecular Biology +17

Clinical Pharmacogenetics Implementation Consortium Guideline for <scp>Cytochrome P450 (<i>CYP</i>)</scp><i>2D6</i> Genotype and Atomoxetine Therapy

Jacob T. Brown, Jeffrey R. Bishop, Katrin Sangkuhl et al. · Clinical Pharmacology & Therapeutics · 2019 · 197 citations · Full text

Medicine, Pharmacology, Pharmacotherapy +17

Disposition and Metabolic Fate of Atomoxetine Hydrochloride: The Role of CYP2D6 in Human Disposition and Metabolism

John‐Michael Sauer, G. Douglas Ponsler, Edward L. Mattiuz et al. · Drug Metabolism and Disposition · 2003 · 151 citations

Medicine, Pharmacokinetics, Pharmacology +16