Concepedia

High Soluble Fiber Promotes Colorectal Tumorigenesis Through Modulating Gut Microbiota and Metabolites in Mice

Jia Yang, Wei Hong, Yufeng Lin, Eagle SH Chu, Yunfei Zhou, Hongyan Gou, Shang Guo, Harry Cheuk-Hay Lau, Alvin H.K. Cheung, Huarong Chen,

Gastroenterology · 2023 · 74 citations · 25 references

DOIFull text

Open access

Abstract

High-dose soluble but not insoluble fiber potentiates colorectal tumorigenesis in a dose-dependent manner by dysregulating gut microbiota and metabolites in mice.

References

25

Cancer statistics, 2020

Rebecca L. Siegel, Kimberly D. Miller, Ahmedin Jemal · CA A Cancer Journal for Clinicians · 2020 · 21K citations · Full text

A gut bacterial pathway metabolizes aromatic amino acids into nine circulating metabolites

Dylan Dodd, Matthew H. Spitzer, William Van Treuren et al. · Nature · 2017 · 1.3K citations · Full text

, , +12

Metagenomic analysis of faecal microbiome as a tool towards targeted non-invasive biomarkers for colorectal cancer

Jun Yu, Qiang Feng, Sunny H. Wong et al. · Gut · 2015 · 1.3K citations · Full text

Microbiome-derived inosine modulates response to checkpoint inhibitor immunotherapy

Lukas F. Mager, Regula Burkhard, Nicola Pett et al. · Science · 2020 · 1.2K citations

Gut mucosal microbiome across stages of colorectal carcinogenesis

Geicho Nakatsu, Xiangchun Li, Haokui Zhou et al. · Nature Communications · 2015 · 685 citations · Full text