The arginase 1/ornithine decarboxylase pathway suppresses HDAC3 to ameliorate the myeloid cell inflammatory response: implications for retinal ischemic injury

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

Gillian M. Tannahill, Annie M. Curtis, Juraj Adamik et al. · Nature · 2013 · 3.8K citations · Full text

Inflammation, Cytokine, Inflammatory Disease +10

Pyruvate Kinase M2 Regulates Hif-1α Activity and IL-1β Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages

Eva M. Pålsson‐McDermott, Annie M. Curtis, Gautam Goel et al. · Cell Metabolism · 2015 · 1.3K citations · Full text

Inflammation, Cytokine, Pyruvate Kinase M2 +10

PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation

Min Xie, Yan Yu, Rui Kang et al. · Nature Communications · 2016 · 538 citations · Full text

Requirement for the histone deacetylase Hdac3 for the inflammatory gene expression program in macrophages

Xuefen Chen, Iros Barozzi, Alberto Termanini et al. · Proceedings of the National Academy of Sciences · 2012 · 383 citations · Full text

Histone Deacetylases, Inflammatory Lung Disease, Immunology +24

Deletion of Histone Deacetylase 3 Reveals Critical Roles in S Phase Progression and DNA Damage Control

Srividya Bhaskara, Brenda Chyla, Joseph M. Amann et al. · Molecular Cell · 2008 · 377 citations · Full text

Histone Modifications, Chromatin, Genome Instability +11