Concepedia

Publication | Open Access

DPP9 Stabilizes NRF2 to Suppress Ferroptosis and Induce Sorafenib Resistance in Clear Cell Renal Cell Carcinoma

DOIFull Paper Access

87

Citations

38

References

2023

Year

Kun Chang, Yingji Chen, Xuanzhi Zhang, Wei Zhang, Ning Xu, Bohan Zeng, Yue Wang, Tao Feng, Bo Dai, Fujiang Xu,
Cancer Research

Abstract

DPP9 overcomes oxidative stress and suppresses ferroptosis in ccRCC by binding to KEAP1 and promoting NRF2 stability, which drives tumor development and sorafenib resistance.

References

YearCitations

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