CD7 targeted “off-the-shelf” CAR-T demonstrates robust in vivo expansion and high efficacy in the treatment of patients with relapsed and refractory T cell malignancies

Molecular remission of infant B-ALL after infusion of universal TALEN gene-edited CAR T cells

Waseem Qasim, Hong Zhan, Sujith Samarasinghe et al. · Science Translational Medicine · 2017 · 888 citations · Full text

Life Sciences, Immunology, Oncology +17

CD7-edited T cells expressing a CD7-specific CAR for the therapy of T-cell malignancies

Diogo Gomes‐Silva, Madhuwanti Srinivasan, Sandhya Sharma et al. · Blood · 2017 · 463 citations · Full text

Life Sciences, Immunology, Oncology +16

T-cell acute lymphoblastic leukemia in adults: clinical features, immunophenotype, cytogenetics, and outcome from the large randomized prospective trial (UKALL XII/ECOG 2993)

David I. Marks, Elisabeth Paietta, Anthony V. Moorman et al. · Blood · 2009 · 416 citations · Full text

Medicine, Hematology, Oncology +17

An “off-the-shelf” fratricide-resistant CAR-T for the treatment of T cell hematologic malignancies

Matthew Cooper, Jaebok Choi, Karl Staser et al. · Leukemia · 2018 · 394 citations · Full text

Medicine, Hematology, Oncology +14

Donor-Derived CD7 Chimeric Antigen Receptor T Cells for T-Cell Acute Lymphoblastic Leukemia: First-in-Human, Phase I Trial

Jing Pan, Yue Tan, Guoling Wang et al. · Journal of Clinical Oncology · 2021 · 294 citations

Life Sciences, Hematology, Immunology +15