Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma

Michele Ceccarelli, Floris P Barthel, Tathiane M. Malta, +202

Cell

Neuro-oncologyTumor BiologyEngineeringTumor HeterogeneityComputational Biology +10

Structures of the Omicron spike trimer with ACE2 and an anti-Omicron antibody

Wanchao Yin, Youwei Xu, Peiyu Xu, +22

Science

Virus StructureViral EvolutionOmicron Spike TrimerAnti-omicron AntibodyViral Pathogenesis +8

Phase II Multicenter, Randomized, Double-Blind Controlled Study of Efficacy and Safety of Umbilical Cord–Derived Mesenchymal Stromal Cells in the Prophylaxis of Chronic Graft-Versus-Host Disease After HLA-Haploidentical Stem-Cell Transplantation

Lei Gao, Yanqi Zhang, Baoyang Hu, +15

Journal of Clinical Oncology

Diagnostic evaluation of a deep learning model for optical diagnosis of colorectal cancer

Dejun Zhou, Fei Tian, Xiangdong Tian, +20

Nature Communications

Bi-paratopic and multivalent VH domains block ACE2 binding and neutralize SARS-CoV-2

Colton J. Bracken, Shion A. Lim, Paige Solomon, +9

Nature Chemical Biology

Ace2 BindingNatural SciencesMolecular BiologyChemistryViral Structural Protein +2

Targeting FLT3 in acute myeloid leukemia using ligand-based chimeric antigen receptor-engineered T cells

Ying Wang, Yingxi Xu, Saisai Li, +8

Journal of Hematology & Oncology

Eradication of T-ALL Cells by CD7-targeted Universal CAR-T Cells and Initial Test of Ruxolitinib-based CRS Management

Shiqi Li, Xinxin Wang, Zhongtao Yuan, +20

Clinical Cancer Research

CD33-Specific Chimeric Antigen Receptor T Cells with Different Co-Stimulators Showed Potent Anti-Leukemia Efficacy and Different Phenotype

Saisai Li, Zhongfei Tao, Yingxi Xu, +10

Human Gene Therapy

Cell TherapyT-regulatory CellImmunologyAntigen ProcessingImmunotherapeutics +18

Structural and biochemical mechanism for increased infectivity and immune evasion of Omicron BA.2 variant compared to BA.1 and their possible mouse origins

Youwei Xu, Canrong Wu, Xiaodan Cao, +12

Cell Research

A Bcma and CD19 Bispecific CAR-T for Relapsed and Refractory Multiple Myeloma

Hua Zhang, Lei Gao, Li Liu, +16

Blood