Concepedia

Combined inhibition of topoisomerase I and poly(ADP-ribose) polymerase: A synergistic therapeutic strategy for glioblastoma with phosphatase and tensin homolog deficiency

Olga Kim, Madison Butler, Zach Sergi, Robert W. Robey, Meili Zhang, Raj Chari, Ying Pang, Guangyang Yu, Wei Zhang, Hua Song,

Neuro-Oncology Advances · 2023 · 14 citations · 34 references

DOIFull text

Open access

Abstract

Our findings provide a proof of concept for the combined treatment with LMP400 and Niraparib in a subset of GBM patients with PTEN deficiency.

References

34

Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1

Roel G.W. Verhaak, Katherine A. Hoadley, Elizabeth Purdom et al. · Cancer Cell · 2010 · 7.5K citations · Full text

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Drug Combination Studies and Their Synergy Quantification Using the Chou-Talalay Method

Ting‐Chao Chou · Cancer Research · 2010 · 5.5K citations

DNA Double-stranded Breaks Induce Histone H2AX Phosphorylation on Serine 139

Emmy P. Rogakou, Duane R. Pilch, Ann H. Orr et al. · Journal of Biological Chemistry · 1998 · 5.3K citations · Full text

The Somatic Genomic Landscape of Glioblastoma

Cameron Brennan, Roel G.W. Verhaak, Aaron McKenna et al. · Cell · 2013 · 5K citations · Full text

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Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors

Junko Murai, Shar-yin N. Huang, Benu Brata Das et al. · Cancer Research · 2012 · 2.1K citations · Full text