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Magic shotgun approach to anti-inflammatory pharmacotherapy: Synthesis of novel thienopyrimidine monomers/heterodimer as dual COX-2 and 15-LOX inhibitors endowed with potent antioxidant activity

Sara Elsayed, Ahmed S. Abdelkhalek, Samar Rezq, Mansour E. Abu Kull, Damián G. Romero, Hend Kothayer

European Journal of Medicinal Chemistry · 2023 · 19 citations · 48 references

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48

Lanthanum Chloride Inhibits LPS Mediated Expressions of Pro-Inflammatory Cytokines and Adhesion Molecules in HUVECs: Involvement of NF-κB-Jmjd3 Signaling

Min Xiu, Juanjuan Xing, Shaoqing Yu et al. · Cellular Physiology and Biochemistry · 2017 · 5.7K citations · Full text

COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: Cloning, structure, and expression

Naduviladath Vishvanath Chandrasekharan, Hu Dai, Katarina Roos et al. · Proceedings of the National Academy of Sciences · 2002 · 2K citations · Full text

Flexibility of the NSAID binding site in the structure of human cyclooxygenase-2

Christine Luong, Aaron B. Miller, Jim Barnett et al. · Nature Structural Biology · 1996 · 615 citations

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A Single Amino Acid Difference between Cyclooxygenase-1 (COX-1) and −2 (COX-2) Reverses the Selectivity of COX-2 Specific Inhibitors

James K. Gierse, Joseph J. McDonald, Scott D. Hauser et al. · Journal of Biological Chemistry · 1996 · 410 citations · Full text

Design, synthesis and anticancer evaluation of thieno[2,3-d]pyrimidine derivatives as dual EGFR/HER2 inhibitors and apoptosis inducers

Souad A. El‐Metwally, Khaled F. Saied, Ibrahim H. Eissa et al. · Bioorganic Chemistry · 2019 · 176 citations

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