Hend Kothayer

RAD6 promotes DNA repair and stem cell signaling in ovarian cancer and is a promising therapeutic target to prevent and treat acquired chemoresistance

Ranganatha R. Somasagara, Sebastian M. Spencer, Kaushlendra Tripathi et al. · Oncogene · 2017 · 70 citations · Full text

Genome Instability, Oncology, Medicine +9

Novel Inhibitors of Rad6 Ubiquitin Conjugating Enzyme: Design, Synthesis, Identification, and Functional Characterization

Matthew A. Sanders, Ghali Brahemi, Pratima Nangia‐Makker et al. · Molecular Cancer Therapeutics · 2013 · 62 citations · Full text

Synthesis and in vitro anticancer evaluation of some 4,6-diamino-1,3,5-triazine-2-carbohydrazides as Rad6 ubiquitin conjugating enzyme inhibitors

Hend Kothayer, Sebastian M. Spencer, Kaushlendra Tripathi et al. · Bioorganic & Medicinal Chemistry Letters · 2016 · 61 citations · Full text

Medicinal Chemistry, Biochemistry, Medicine +8

Gold nanoparticle conjugated Rad6 inhibitor induces cell death in triple negative breast cancer cells by inducing mitochondrial dysfunction and PARP-1 hyperactivation: Synthesis and characterization

Brittany Haynes, Yanhua Zhang, Fangchao Liu et al. · Nanomedicine Nanotechnology Biology and Medicine · 2015 · 49 citations · Full text

Nanomedicine, Mitochondrial Dysfunction, Gold Nanoparticle +10

Design and synthesis of novel quinazolinones conjugated ibuprofen, indole acetamide, or thioacetohydrazide as selective COX-2 inhibitors: anti-inflammatory, analgesic and anticancer activities

Asmaa Sakr, Samar Rezq, Samy M. Ibrahim et al. · Journal of Enzyme Inhibition and Medicinal Chemistry · 2021 · 46 citations · Full text