Concepedia

Novel tripeptide RKH derived from <i>Akkermansia muciniphila</i> protects against lethal sepsis

Shihao Xie, Jiaxin Li, Fengyuan Lyu, Qingming Xiong, Peng Gu, Yuqi Chen, Meiling Chen, Jingna Bao, Xianglong Zhang, Rongjuan Wei,

Gut · 2023 · 90 citations · 37 references

DOIFull text

Open access

Abstract

We revealed that a novel tripeptide, RKH, derived from live AKK, may act as a novel endogenous antagonist for TLR4. RKH may serve as a novel potential therapeutic approach to combat lethal sepsis after successfully translating its efficacy into clinical practice.

References

37

Global, regional, and national sepsis incidence and mortality, 1990–2017: analysis for the Global Burden of Disease Study

Kristina E. Rudd, Sarah Charlotte Johnson, Kareha M Agesa et al. · The Lancet · 2020 · 7.1K citations · Full text

The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research

Nathalie Percie du Sert, Viki Hurst, Amrita Ahluwalia et al. · PLoS Biology · 2020 · 5.1K citations · Full text

, , +12

The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex

Beom Seok Park, Dong Hyun Song, Ho Min Kim et al. · Nature · 2009 · 2.3K citations

, , +6

Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study

Clara Depommier, Amandine Everard, Céline Druart et al. · Nature Medicine · 2019 · 2.1K citations · Full text

, , +10

A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice

Hubert Plovier, Amandine Everard, Céline Druart et al. · Nature Medicine · 2016 · 2K citations · Full text

, , +9