Precision Health in the Age of Large Language Models

Abstract

Medicine today is imprecise. Among the top 20 drugs in the U.S., up to 80% of patients are non-responders. The goal of precision health is to provide the right intervention for the right people at the right time. The key to realize this dream is to develop a data-driven, learning system that can instantly incorporate new health information to optimize care delivery and accelerate biomedical discovery. In reality, however, the health ecosystem is mired in overwhelming unstructured data and excruciating manual processing. For example, in cancer, standard of care often fails, and clinical trials are the last hope. Yet less than 3% of patients could find a matching trial, whereas 40% of trial failures simply stem from insufficient recruitment. Discovery is painfully slow as a new drug may take billions of dollars and over a decade to develop.