Evaluation of RNAi therapeutics VIR-2218 and ALN-HBV for chronic hepatitis B: Results from randomized clinical trials

References

Page 1

	Year	Citations
EASL 2017 Clinical Practice Guidelines on the management of hepatitis B virus infection Pietro Lampertico, Kosh Agarwal, Thomas Berg, Journal of Hepatology Hepatitis DViral HepatitisHepatitis BHepatitisAntiviral Therapy	2017	5.3K
Multivalent <i>N</i>-Acetylgalactosamine-Conjugated siRNA Localizes in Hepatocytes and Elicits Robust RNAi-Mediated Gene Silencing Jayaprakash K. Nair, Jennifer L. S. Willoughby, Amy Chan, Journal of the American Chemical Society	2014	1K
Hepatitis B virus X protein identifies the Smc5/6 complex as a host restriction factor Adrien Decorsière, H. Mueller, Pieter C. Van Breugel, Nature Host Restriction FactorHost FactorMolecular VirologyViral HepatitisPathogenesis	2016	520
RNAi-based treatment of chronically infected patients and chimpanzees reveals that integrated hepatitis B virus DNA is a source of HBsAg Christine I. Wooddell, Man‐Fung Yuen, Henry Lik‐Yuen Chan, Science Translational Medicine	2017	477
High antigen levels are the cause of T cell exhaustion during chronic viral infection Scott N. Mueller, Rafi Ahmed Proceedings of the National Academy of Sciences High Antigen LevelsMhc ClassAdaptive Immune SystemCellular ImmunologyImmunology	2009	395
Requirements for global elimination of hepatitis B: a modelling study Shevanthi Nayagam, Mark Thursz, Elisa Sicuri, The Lancet Infectious Diseases	2016	374
Hepatitis B virus genotypes in the United States: results of a nationwide study Chi—Jen Chu, Emmet B. Keeffe, Steven—Huy Han, Gastroenterology Hepatitis DViral HepatitisMedicineHepatitis BHepatitis	2003	306
Circulating and intrahepatic antiviral B cells are defective in hepatitis B Alice R. Burton, Laura J. Pallett, Laura E. McCoy, Journal of Clinical Investigation	2018	303
Investigating the pharmacodynamic durability of GalNAc–siRNA conjugates Christopher R. Brown, Swati Gupta, June Qin, Nucleic Acids Research Sirna AccumulationMolecular PharmacologyMedicinal ChemistryPharmaceutical ScienceFunctional Sirna	2020	265
Selection of GalNAc-conjugated siRNAs with limited off-target-driven rat hepatotoxicity Maja M. Janas, Mark K. Schlegel, Carole E. Harbison, Nature Communications	2018	255

Page 1